The HardyWeinberg Package
نویسنده
چکیده
This guide gives some instructions on how to perform graphical significance tests for HardyWeinberg equilibrium (HWE) by depicting the acceptance region for HWE in a ternary plot with routines from the package HardyWeinberg. The outline of this guide is as follows. Section 2 describes how the R package HardyWeinberg can be installed. Section 3 shows how to perform some of the classical tests for Hardy-Weinberg equilibrium with routines from the package. Finally, Section 4 shows how to contruct ternary plots with the HW acceptance region and how to perform graphical tests for HWE. We refer to Graffelman & Morales (2008) for the theoretical foundation of the graphical tests. If you appreciate this software then please cite the following paper in your work:
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Exploring Diallelic Genetic Markers: The HardyWeinberg Package
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Am J Epidemiol Vol. 154, No. 3, 2001 portions.” (Letter). Am J Epidemiol 2001;154:287. 2. Schaid DJ, Jacobsen SJ. Biased tests of association: comparisons of allele frequencies when departing from HardyWeinberg proportions. Am J Epidemiol 1999;149:706–11. 3. Armitage P. Tests for linear trends in proportions and frequencies. Biometrics 1955;11:375–86. Daniel J. Schaid Steven J. Jacobsen Departm...
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